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Andrew Jheon D.D.S., Ph.D

Mechanistic understanding of tooth development and tooth movements

Andrew Jheon D.D.S., Ph.D

My research interests lie in understanding the development of teeth and orthodontic tooth movement. This involves a wide spectrum of questions such as:

How do teeth form? Are there other functions of teeth besides mastication, particularly in systemic health? Can teeth be used as diagnostic markers of systemic disease? How do teeth move within the alveolar bone during eruption and orthodontic treatment? Can we induce human teeth to grow continuously like rodent incisors? The answers to such questions may lead to improvements in the prevention, diagnosis, and/or treatment of dental-related problems in the clinic.

We have generated several mouse models with fascinating tooth phenotypes and are currently uncovering the molecular mechanisms responsible for the phenotypes. We also have numerous mouse studies underway looking at the roles of soft and hard food diets on craniofacial morphology, the effects of inferior alveolar nerve block on third molar agenesis, and gene expression profiling during orthodontic tooth movement. 

Selected publications:

Goodwin, A.F., W.E. Tidyman*, A.H. Jheon*, A. Shari, X. Zheng, C. Charles, J.A. Fagin, M. McMahon, T.G.H. Diekwisch, B. Ganss, K.A. Rauen, and O.D. Klein (2013) Ras signaling negatively regulates enamel formation. Human Mol. Genetics. doi: 10.1093/hmg/ddt455. *equal contribution.

H. Cao*, A. H. Jheon*, X. Li, J. Wang, S. Flores, Z. Sun, Z. Zhang, M. McManus, O. D. Klein, and B. A. Amendt (2013) A Pitx2-miRNA-200c-noggin regulatory pathway regulates BMP signaling and mesenchyme-epithelial transition. Development 140, 3348-3359. doi: 10.1242/dev.089193*equal contribution. PMCID: PMC3737717.

A. H. Jheon*, K. Seidel*, B. Biehs, and O. D. Klein (2013) From molecules to mastication: the development and evolution of tooth development. WIREs Dev Biol 2:165-182. doi: 10.1002/wdev.63. *equal contribution. PMCID: PMC3632217.

P. Purcell, A. H. Jheon, H. Rahimi, Adriane Joo, and O. D. Klein (2012) Spry1 and Spry2 are essential for development of the temporomandibular joint. J. Dent. Res. 91(4):387-93. PMCID: PMC3310757.

A. H. Jheon, P. Mostowfi, M. L. Snead, R. A. Ihrie, E. Sone, T. Pramparo, L. D. Attardi, and O. D. Klein (2011) PERP is critical for enamel formation via effects on desmosome-mediated adhesion and on gene expression. J. Cell Sci. 124, 745-754. doi: 10.1242/jcs.078071. PMCID: PMC3039019.

C. I. Petersen*, A. H. Jheon*, P. Mostowfi, C. Charles, S. Ching, S. Thirumangalathu, L. A.Barlow, and O. D. Klein (2011) FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. PLoS Genetics 7(6), e10020981. doi: 10.1371/journal.pgen.1002098. *equal contribution. PMCID: PMC3107195.

C. Charles, M. Hovorakova, Y. Ahn, D. Lyons, P. Marangoni, S. Churava, B. Biehs, A. Jheon, H. Lesot, G. Balooch, R. Krumlauf, L. Viriot, R. Peterkova,  and O. D. Klein (2011) Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling. Development 138(18):4063-73. doi: 10.1242/dev.069195. PMCID: PMC3160100.

A. H. Jheon, C. Li, T. Wen, F. Michon, and O. D. Klein (2011) Expression of microRNAs in the stem cell niche of the adult mouse incisor. PLoS One 6(9):e24536. doi: 10.1371/journal.pone.0024536. PMCID: PMC3169592.

A. H. Jheon and R.A. Schneider (2009) The cells that fill the bill: Neural crest and the evolution of craniofacial development. J. Dent. Res. 88(1), 12-21. PMCID: PMC3317957.

A. H. Jheon, A. Bansal, B Zhu, B. Ganss, S. Cheifetz. and J. Sodek (2009) Characterization of the constitutive over-expression of AJ18 in a novel rat stromal bone marrow cell line (D8-SBMCs). Arch. Oral Biol. 54(8):705-16. doi: 10.1016/j.archoralbio.2009.04.007.