Ophir Klein M.D., Ph.D.
Genetic regulation of dental stem cells and craniofacial and tooth morphogenesis
Embryonic development is one of the most beautiful processes in nature. However, when developmental processes go awry, then birth defects, cancer and other diseases can result. Our research is centered on understanding how development normally occurs in the hope of one day treating diseases that result from abnormalities in these processes. We focus largely on craniofacial and dental development, as malformations in these organs are among the most common congenital abnormalities and have profound impacts on the lives of patients and their families. We also study normal and perturbed development of the skeleton, taste papillae, external genitalia, gastrointestinal tract, and other organs, and we investigate how embryonic and adult stem cells self-renew and differentiate.
Petersen, CI, Jheon A, Mostowfi P, Charles C, Ching S, Thirumangalathu S, Barlow LA, Klein OD.FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size.PLoS Genetics 2011.
Jheon A, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD.PERP regulates enamel formation via effects on cell–cell adhesion and gene expression.J Cell Sci 2011; 124:745-754.
Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RAD, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD.Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.Development 2010; 137:3753-3761.
Ahn Y, Sanderson BW, Klein OD, Krumlauf R.Inhibition of Wnt signaling by Wise/Sostdc1 and negative feedback from Shh controls tooth number and patterning.Development 2010; 137:3221-3231.
Charles C, Lazzari V, Tafforeau P, Schimmang T, Tekin M, Klein O, Viriot, L.Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition.Proc Natl Acad Sci U S A 2009; 106:22364-8.Click Here to ViewCommentary on our paper in Nature -