Rich Schneider Ph.D.
Craniofacial Morphogenesis and Evolution
- Tel: (415) 502-3788
- Email: email@example.com
- Website: http://orthosurg.ucsf.edu/Richard.Schneider
Dr. Schneider's current research program focuses on molecular and cellular mechanisms underlying development of the musculoskeletal system. He and his lab have been employing an avian chimeric transplantation system to exploit the divergent maturation rates and distinct species-specific anatomies of quail and duck. Specifically, his lab has been exchanging mesenchymal stem cells between quail and duck embryos, which challenges resultant chimeras to assimilate donor versus host-specific differences in growth and morphology. Using this approach, his lab has been identifying genes and signaling interactions that regulate the timing of musculoskeletal tissue differentiation, control size and shape, and which ultimately enable cartilage, bone, and muscle to achieve structural and functional integration. A goal of Dr. Schneider's research is to devise molecular-based therapies for inducing repair and regeneration of musculoskeletal tissues affected by congenital defects, disease, and trauma.
Allon AA, Butcher K, Schneider RA, Lotz JC. Structured bilaminar coculture outperforms stem cells and disc cells in a simulated degenerate disc environment. Spine (Phila Pa 1976). 2012 May 1; 37(10):813-8.
Allon AA, Butcher K, Schneider RA, Lotz JC. Structured coculture of mesenchymal stem cells and disc cells enhances differentiation and proliferation. Cells Tissues Organs. 2012; 196(2):99-106.
Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T. Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthritis Cartilage. 2011 Oct; 19(10):1210-8.
Mitgutsch C, Wimmer C, Sánchez-Villagra MR, Hahnloser R, Schneider RA. Timing of ossification in duck, quail, and zebra finch: intraspecific variation, heterochronies, and life history evolution. Zoolog Sci. 2011 Jul; 28(7):491-500.
Solem RC, Eames BF, Tokita M, Schneider RA. Mesenchymal and mechanical mechanisms of secondary cartilage induction. Dev Biol. 2011 Aug 1; 356(1):28-39.
Zheng L, Zhang Y, He P, Kim J, Schneider R, Bronckers AL, Lyaruu DM, DenBesten PK. NBCe1 in mouse and human ameloblasts may be indirectly regulated by fluoride. J Dent Res. 2011 Jun; 90(6):782-7.
Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T. Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-ß and Runx2 in bone is required for hearing. EMBO Rep. 2010 Oct; 11(10):765-71.
He P, Zhang Y, Kim SO, Radlanski RJ, Butcher K, Schneider RA, DenBesten PK. Ameloblast differentiation in the human developing tooth: effects of extracellular matrices. Matrix Biol. 2010 Jun; 29(5):411-9.
Tokita M, Schneider RA. Developmental origins of species-specific muscle pattern. Dev Biol. 2009 Jul 15; 331(2):311-25.
Jheon AH, Schneider RA. The cells that fill the bill: neural crest and the evolution of craniofacial development. J Dent Res. 2009 Jan; 88(1):12-21.