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Caroline Shiboski D.D.S., M.P.H., Ph.D.

Epidemiology of oral manifestations related to HIV/AIDS and other immune dysfunction, Oral Cancer, and Sjögren’s syndrome; Development and validation of classification criteria for Sjögren’s syndrome; Burden of disease and access to dental care among immunocompromised populations

Caroline Shiboski D.D.S., M.P.H., Ph.D.

Dr. Shiboski is the Leland A. and Gladys K. Barber Distinguished Professor in Dentistry and Chair of the Department of Orofacial Sciences, School of Dentistry.  She obtained her DDS from the Université René Descartes in Paris, and has advanced training in Epidemiology (MPH and PhD from UC Berkeley) and Oral Medicine (she is a certified Diplomate of the American Board of Oral Medicine). She has been a faculty member in the UCSF School of Dentistry since 1994, after initially joining the school as a resident in the Advanced Education in General Dentistry program. Her research experience focuses on the epidemiology of oral manifestations related to immune dysfunction and of Oral Cancer.

Dr. Shiboski has received multiple NIH grants and contracts since 1994. She implemented a collaborative study, funded through the AIDS Fogarty Program, exploring oral candidiasis as a surrogate marker of HIV disease progression among women in Zimbabwe. For over 8 years she lead the NIDCR-funded Oral HIV/AIDS Research Alliance, a Collaborative Science Group of the AIDS Clinical Trial Group (ACTG) Network. The ACTG is the largest AIDS clinical trial network in the world and has been funded by NIAID for more than 25 years.

As principal investigator of the Sjögren’s International Collaborative Clinical Alliance (SICCA) Biorepository, Dr. Shiboski has helped establish new classification criteria for Sjögren’s Syndrome that were provisionally approved by the American College of Rheumatology (ACR).  The other goal of the SICCA contract is to disseminate Sjögren’s syndrome data and biospecimens, collected during the initial 10-year contract, to scientists around the world to advance the field with pathogenesis, epidemiologic, and genetic studies.  She is also leading an international effort to obtain definitive approval from both ACR and the European League Against Rheumatism (EULAR) of a final set of criteria to be used for entry into Sjögren’s syndrome clinical trials. 

Selected publications:

Brown C, Krishnan S, Hursh K, Yu M, Johnson P, Page K, Shiboski CH. Dental disease prevalence among methamphetamine and heroin users in an urban setting: A pilot study. J Am Dent Assoc. 2012 Sep; 143(9):992-1001.

Shiboski SC, Shiboski CH, Criswell L, Baer A, Challacombe S, Lanfranchi H, Schiødt M, Umehara H, Vivino F, Zhao Y, Dong Y, Greenspan D, Heidenreich AM, Helin P, Kirkham B, Kitagawa K, Larkin G, Li M, Lietman T, Lindegaard J, McNamara N, Sack K, Shirlaw P, Sugai S, Vollenweider C, Whitcher J, Wu A, Zhang S, Zhang W, Greenspan J, Daniels T. American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance Cohort. Arthritis Care Res (Hoboken). 2012 Apr; 64(4):475-87.

Malladi AS, Sack KE, Shiboski SC, Shiboski CH, Baer AN, Banushree R, Dong Y, Helin P, Kirkham BW, Li M, Sugai S, Umehara H, Vivino FB, Vollenweider CF, Zhang W, Zhao Y, Greenspan JS, Daniels TE, Criswell LA. Primary Sjögren's syndrome as a systemic disease: A study of participants enrolled in an International Sjögren's syndrome registry. Arthritis Care Res (Hoboken). 2012 Jun; 64(6):911-8.

Tagny CT, Kouao MD, Touré H, Gargouri J, Fazul AS, Ouattara S, Anani L, Othmani H, Feteke L, Dahourou H, Mbensa GO, Molé S, Nébié Y, Mbangue M, Toukam M, Boulahi MO, Andriambelo LV, Rakoto O, Baby M, Yahaya R, Bokilo A, Senyana F, Mbanya D, Shiboski C, Murphy EL, Lefrère JJ. Transfusion safety in francophone African countries: an analysis of strategies for the medical selection of blood donors. Transfusion. 2012 Jan; 52(1):134-43.

Daniels TE, Cox D, Shiboski CH, Schiødt M, Wu A, Lanfranchi H, Umehara H, Zhao Y, Challacombe S, Lam MY, De Souza Y, Schiødt J, Holm H, Bisio PA, Gandolfo MS, Sawaki T, Li M, Zhang W, Varghese-Jacob B, Ibsen P, Keszler A, Kurose N, Nojima T, Odell E, Criswell LA, Jordan R, Greenspan JS. Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjögren's syndrome among 1,726 registry participants. Arthritis Rheum. 2011 Jul; 63(7):2021-30.

Challacombe S, Chidzonga M, Glick M, Hodgson T, Magalhães M, Shiboski C, Owotade F, Ranganathan R, Naidoo S. Global oral health inequalities: oral infections-challenges and approaches. Adv Dent Res. 2011 May; 23(2):227-36.

Shiboski C, Hodgson T, Challacombe SJ. Overview and research agenda arising from the Sixth World Workshop on Oral Health and Disease in AIDS. Adv Dent Res. 2011 Apr; 23(1):7-9.

Shiboski CH, Webster-Cyriaque JY, Ghannoum M, Greenspan JS, Dittmer D. Overview of the oral HIV/AIDS Research Alliance Program. Adv Dent Res. 2011 Apr; 23(1):28-33.

Robbins JL, Wenger L, Lorvick J, Shiboski C, Kral AH. Health and oral health care needs and health care-seeking behavior among homeless injection drug users in San Francisco. J Urban Health. 2010 Dec; 87(6):920-30.

Dollard SC, Butler LM, Jones AM, Mermin JH, Chidzonga M, Chipato T, Shiboski CH, Brander C, Mosam A, Kiepiela P, Hladik W, Martin JN. Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: insights on the origin of the "Kaposi's sarcoma belt". Int J Cancer. 2010 Nov 15; 127(10):2395-401.