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Edward Hsiao M.D., Ph.D.

Understanding how hormone signals affect mesenchymal tissues in normal growth and in disease

Edward Hsiao M.D., Ph.D.

Dr. Hsiao’s research focuses on understanding how hormone and regulatory signals control mesenchymal tissues in normal growth and in disease. His current projects focus on the skeletal system, and include developing a new mouse model for studying G-protein signaling in bone growth and developing human induced pluripotent stem cell (iPSC) models for human genetic bone diseases. By using a wide spectrum of patient-inspired approaches, he hopes to develop a broader understanding of the biology underlying human skeletal development. This new knowledge will help us devise novel therapeutic approaches for treating human skeletal disorders and bone injuries and examine how hormone signals affect other mesenchymal tissues such as fat, muscle, cartilage, and blood vessels.

Dr. Hsiao received his BA magna cum laude in biochemistry and molecular biology from Harvard University. Dr. Hsiao completed his MD and PhD at the Johns Hopkins Medical School. After completing his internal medicine residency at Johns Hopkins, Dr. Hsiao came to the UCSF for his endocrinology fellowship. He is currently an assistant professor at UCSF. Dr. Hsiao is a former California Institute of Regenerative Medicine Clinical Scholar at the Gladstone Institute of Cardiovascular Disease. His work has been recognized by a 2007 Young Investigator Award from the American Society for Bone and Mineral Research, a a 2008 National Osteoporosis Foundation research grant award, and a 2012 March of Dimes Basil O’Connor Starter Award.

Selected publications:

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Hsiao, E.C., Boudignon, B.M., Chang, W.C., Bencsik, M., Peng, J., Nguyen, T.D., Manalac, C., Halloran, B.P., Conklin, B.R., and Nissenson, R.A. (2008). Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A 105(4), 1209-1214. PMCID: PMC2234117.

Hsiao, E.C., Yoshinaga, Y., Nguyen, T.D., Musone, S.L., Kim, J., Swinton, P., Espineda, I., Manalac, C., DeJong, P., and Conklin, B.R. (2008). Marking embryonic stem cells using a 2A self-cleaving peptide: A NKX2-5 Emerald GFP BAC reporter. PLoS One 3(7), e2532. PMCID: PMC2430532.

Hsiao, E.C.*, Millard, S.M.*, Louie, A., Huang, Y., Conklin, B.R., and Nissenson, R.A. (2010). Ligand-mediated activation of an engineered Gs G-protein coupled receptor in osteoblasts increases trabecular bone formation. Mol Endocrinology. 24(3), 621-631. PMCID: PMC2840804.

Hsiao, E.C., Boudignon, B.M., Halloran, B.P., Nissenson, R.A., Conklin, B.R. (2010). Gs G-protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation. J Bone Miner Res. 25(3): 584-593. PMID: 20200944.

Kazakia, G.K., Speer, D., Shanbhag, S., Majumdar, S., Conklin, B.R., Nissenson, R.A., and Hsiao, E.C. (2011). Mineral Composition Is Altered by Osteoblast Expression of an Engineered Gs-Coupled Receptor. Calcified Tissue International 89: 10-20. PMCID: In process.

Schepers, K.*, Hsiao, E.C.*, Garg, T., Scott, M.J., and Passegue, E. (2012). Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice. Blood 120(17), 3425-3435. PMCID: PMC3482855. (Cover)

Schafer, A.L., Mumm, S., El-Sayed, I., McAlister, W.H., Horvai, A.E., Tom, A.M., Hsiao, E.C., Schaefer, F.V., Collins, M.T., Anderson, M.S., Whyte, M.P., and Shoback, D.M. (2013). Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 28(11). (Cover) PMCID: in progress

Matsumoto, Y.*, Hayashi, Y.*, Schlieve, C.R.*, Ikeya, M., Kim, H., Nguyen, T.D., Sami, S., Baba, S., Barruet, E., Nasu, A., Asaka, I., Otsuka, T., Yamanaka, S., Conklin, B.R., Toguchida, J., and Hsiao, E.C. (2013). Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation. Orphanet Journal of Rare Diseases 8(1): 190. PMID 24321451 (*, equal contributors). PMCID: in progress

Bershteyn, M., Hayashi, Y., Desachy, G., Hsiao, E.C., Sami, S., Tsang, K.M., Weiss, L.A., Kriegstein, A.R., Yamanaka, S., and Wynshaw-Boris, A. (2014). Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells. Nature advance online publication. PMCID in progress.