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John S. Greenspan B.Sc., B.D.S., Ph.D., F.R.C.Path, Sc.D., F.D.S.R.C.S. (ENG), F.K.C.

Global Health Sciences, Oral issues and AIDS

John S. Greenspan B.Sc., B.D.S., Ph.D., F.R.C.Path, Sc.D., F.D.S.R.C.S. (ENG), F.K.C.

My major scholarly and clinical interest for the last thirty-plus years has been the impact on the mouth and on the health sciences of HIV and AIDS. This has led to a focus on broader aspects of global health sciences, oral issues and AIDS being the most significant to me. My colleagues and I have been privileged to make contributions that have been of broad significance in the diagnosis and care of patients with HIV infection. This work has brought me into contact with a wide array of people, problems and issues worldwide in academic and community health care, in basic, clinical and social/behavioral biomedical science as well as in industry. This has extended into the political arena statewide, nationally and internationally as we have sought and defended funding for research work in our field and for dental and medical research in general, for care for HIV-infected people and concerning broader issues of neglect, stigma, poverty and disparity in global health. My leadership roles in UCSF’s AIDS activities culminated in my becoming Director of the campus-wide AIDS Research Institute 2003-2012. My work has led to extensive media contact, including television, radio and the press and I have learned to respect their role in presenting our work to the public. Similarly, I have come to work with and develop mutually supportive relationships with community representatives and groups, including activists. I have been able to continue my research while assuming significant administrative responsibilities and have ventured into areas of global health beyond my original focus on oral health and on AIDS. I have been very active in the growing Global Health Sciences Program at UCSF and also led for seven years the Sjögren’s Syndrome registry [SICCA].

As Associate Dean for Global Oral Health, indeed in most of my leadership roles, I offer a bridge between Dentistry and the other health sciences and ensure that our field both takes innovation and momentum from the mainstream while contributing to it in many ways. I try to bring elements of that set of experiences and skills to bear on elevating the relevant programs of the School to their rightful place of preeminence, identify and nurture new investigators and clinician scholars in oral global health and foster new initiatives.

Selected publications:

Greenspan JS. Global health and dental education: a tipping point? J Dent Educ. 2013 Oct; 77(10):1243-4. 

De Souza YG, Greenspan JS. Biobanking past, present and future: responsibilities and benefits. AIDS. 2013 Jan 28; 27(3):303-12. 

Baer AN, Gourin CG, Westra WH, Cox DP, Greenspan JS, Daniels TE. Rare diagnosis of IgG4-related systemic disease by lip biopsy in an international Sjögren syndrome registry. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Mar; 115(3):e34-9. 

Ryder MI, Nittayananta W, Coogan M, Greenspan D, Greenspan JS. Periodontal disease in HIV/AIDS. Periodontol 2000. 2012 Oct; 60(1):78-97. 

Burbelo PD, Kovacs JA, Wagner J, Bayat A, Rhodes CS, De Souza Y, Greenspan JS, Iadarola MJ. The Cancer-Associated Virus Landscape in HIV Patients with Oral Hairy Leukoplakia, Kaposi's Sarcoma, and Non-Hodgkin Lymphoma. AIDS Res Treat. 2012; 2012:634523. 

Shiboski SC, Shiboski CH, Criswell L, Baer A, Challacombe S, Lanfranchi H, Schiødt M, Umehara H, Vivino F, Zhao Y, Dong Y, Greenspan D, Heidenreich AM, Helin P, Kirkham B, Kitagawa K, Larkin G, Li M, Lietman T, Lindegaard J, McNamara N, Sack K, Shirlaw P, Sugai S, Vollenweider C, Whitcher J, Wu A, Zhang S, Zhang W, Greenspan J, Daniels T. American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken). 2012 Apr; 64(4):475-87.

Malladi AS, Sack KE, Shiboski SC, Shiboski CH, Baer AN, Banushree R, Dong Y, Helin P, Kirkham BW, Li M, Sugai S, Umehara H, Vivino FB, Vollenweider CF, Zhang W, Zhao Y, Greenspan JS, Daniels TE, Criswell LA. Primary Sjögren's syndrome as a systemic disease: a study of participants enrolled in an international Sjögren's syndrome registry. Arthritis Care Res (Hoboken). 2012 Jun; 64(6):911-8.

Coogan MM, Xu T, Yu G-Y, Greenspan J, Challacombe SJ.(editors) “The Mouth and AIDS: The Global Challenge Sixth World Workshop on Oral Health and Disease in AIDS, April 21-24, 2009” Adv Dent Res 23; No 1, April 2011.

Daniels TE, Cox D, Shiboski CH, Schiødt M, Wu A, Lanfranchi H, Umehara H, Zhao Y, Challacombe S, Lam MY, De Souza Y, Schiødt J, Holm H, Bisio PA, Gandolfo MS, Sawaki T, Li M, Zhang W, Varghese-Jacob B, Ibsen P, Keszler A, Kurose N, Nojima T, Odell E, Criswell LA, Jordan R, Greenspan JS. Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjögren's syndrome among 1,726 registry participants. Arthritis Rheum. 2011 Jul; 63(7):2021-30.

Shiboski CH, Webster-Cyriaque JY, Ghannoum M, Greenspan JS, Dittmer D. Overview of the oral HIV/AIDS Research Alliance Program. Adv Dent Res. 2011 Apr; 23(1):28-33.

Whitcher JP, Shiboski CH, Shiboski SC, Heidenreich AM, Kitagawa K, Zhang S, Hamann S, Larkin G, McNamara NA, Greenspan JS, Daniels TE. A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sjögren's Syndrome International Registry. Am J Ophthalmol. 2010 Mar; 149(3):405-15. 

Shiboski CH, Patton LL, Webster-Cyriaque JY, Greenspan D, Traboulsi RS, Ghannoum M, Jurevic R, Phelan JA, Reznik D, Greenspan JS. The Oral HIV/AIDS Research Alliance: updated case definitions of oral disease endpoints. J Oral Pathol Med. 2009 Jul; 38(6):481-8. 

Daniels TE, Criswell LA, Shiboski C, Shiboski S, Lanfranchi H, Dong Y, Schiødt M, Umehara H, Sugai S, Challacombe S, Greenspan JS. An early view of the international Sjögren's syndrome registry. Arthritis Rheum. 2009 May 15; 61(5):711-4. 

Rao UKM, Kannan R, Srivatsan P, Ramachandran H, Rajasekaran ST, Kumarasamy N, Solomon S, Greenspan JS. “Oral lesions among persons with HIV disease with and without highly active antiretroviral therapy (HAART) in southern India” J Oral Pathol Med 36:136-141, 2007.

Tugizov S, Herrera R, Veluppillai P, Greenspan JS, Greenspan D, Palefsky J. “EBV-infected monocytes facilitate dissemination of EBV within the oral mucosal epithelium”, J Med Virol 81: 5484-5496, 2007.


ARI, SoM            

Dept. of Pathology, SoM
OP, SoD             
GOH, SoD