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Ling Zhan D.D.S., Ph.D.

Dental caries: Fighting an infectious disease from bench to chair-side

Ling Zhan D.D.S., Ph.D.

Dr. Zhan’s primary research interest is to understand microbiological aspects of dental caries and identify protocols that will lead to prevention or elimination of dental caries in children. One of her research focus is on virulence factors of mutans streptococci and other caries-causing bacteria that are related to their transmission or initiation of dental decay. The overall goal of these studies is to identify specific genes in MS that are related to development of dental caries in children and investigate whether these genes can be used to screen children with high risk for antimicrobial treatment and also to develop targeted antimicrobial agent for caries prevention in children. The other aspect of her research is focused on seeking clinical regimens in caries prevention. She has conducted randomized clinical trails to identify effective practical antimicrobial regimens, such as povidone iodine and xylitol products, which may alter caries-causing bacteria challenge and prevent new caries in children.

The third aspect oh her research is to study and develop an effective and practical Caries Management by Risk Assessment protocol (CAMBRA) for children.

She is also interested in global oral health projects and recently engaged study on investigating the feasibility and efficacy of incorporating oral health education and fluoride varnish program through pediatric immunization clinic in Roatan, Honduras with a joint effort of a multidisciplinary team from UCSF and UC Berkley.

Selected publications:

G. Khoo, L. Zhan, C. Hoover, J.D. Featherstone. Cariogenic virulence characteristics of mutans streptococci isolated from caries-active and caries-free adults.  J Calif Dent Assoc. 2005 Dec;33(12):973-80.

L. Zhan, J. D.B. Featherstone, S. A.  Gansky, C. I. Hoover, T Fujino, R J Berkowitz, P K. Den Besten.  Antibacterial Treatment Needed for Severe Early Childhood Caries. J Public Health Dent. 2006 Summer;66(3):174-9.

S. Doméjean-Orliaguet, L. Zhan, P.K. Denbesten, J. Stamper, W.T. Boyce, J.D.Featherstone. Horizontal Transmission of Mutans Streptococci in Children. J. Dent. Research. 2010 Jan;89(1):51-55.

W. T. Boyce; P. K. Den Besten; J. Stamperdahl, L. Zhan, Y. Jiang; N. E Adler,J. D Featherstone Social Inequalities in Childhood Dental Caries: The Convergent Roles of Stress, Bacteria and Disadvantage. Soc Sci Med. 2010 Nov;71(9):1644-52. PMID: 20870333

J.D.B. Featherstone, J.M. White, C.I. Hoover, M. Rapozo-Hilo, J.A. Weintraub, R.S. Wilson, L. Zhan, and S.A. Gansky. A Randomised Clinical Trial of Caries Management by Risk Assessment. Caries Res. 2012 Apr 3;46(2):118-129.

L. Zhan, J. Cheng, M. Ngo, P. Cheng, P. Den Besten , C.I. Hoover C, J. D.B. Featherstone. Effects of Xylitol Wipes on Cariogenic Bacteria and Caries in Young Children. J Dent Res. 2012 July 91: S85-S90

L. Zhan, S. Tan, P. K. Den Besten, J.D.B. Featherstone, C. Hoover. Factors Related to Maternal Transmission of Mutans Streptococci in High-Risk Children -Pilot Study. J. Pediatric. Dent. 2012 August 34 (4): e86-91

L. Zhan, J.D.B. Featherstone, J. Lo, C. Krupansky,  N. Hoang. Clinical Efficacy and Effect of Xylitol-Wipes on Bacterial Virulence. Adv. Dent. Res. 2012 September 24 (2): 117 - 122

J.A. Horst, U. Pieper, A. Sali, L. Zhan, G. Chopra, R. Samudrala, J.D.B. Featherstone. Strategic protein target analysis for developing drugs to stop dental caries. Adv. Dent. Res. 2012 Sep;24(2):86-93.

Zhan L, Cheng J, Kim S, Zavery P, DenBesten PK, Featherstone JDB,  Hoover CI. Effectiveness of Povidone-Iodine Foam in Caries Prevention in High-Risk Children. J Dent Res (submitted and under revision

J. Golinveaux, B. Gerbert, J. Cheng, K. Duderstadt, A. Alkon, B. Lin, A. Miller, L. Zhan. Oral Health Education for Pediatric Nurse Practitioner Students. J Dent Educ. 2013 May;77(5):581-90.