Noelle L Etoile Ph.D.
Mechanisms of Cellular and Behavioral Plasticity
- Tel: (415) 476-6850
- Email: firstname.lastname@example.org
Our focus has been on the cell biological processes that promote and maintain sensory signaling and neuronal plasticity throughout development. Neurons are the front-line of an organism’s response to its environment. Thus, understanding how their signaling components organize to perceive and transmit information both in response to novel and persistent cues is key to understanding behavior. We are testing the hypothesis that signaling pathways act via small RNAs to modify chromatin thereby allowing for experience-dependent changes in the output response. We utilize C. elegans for our investigations because this nematode, with only 1,000 cells and 302 neurons exhibits robust behavioral plasticity and we can use cell biological, genetic, behavioral, physiological and molecular techniques to understand the molecular details that underlie experience driven changes in behavior. The molecular and cellular logic that underlies behavioral plasticity in C. elegans is likely to be utilized in the nervous system of higher organisms and humans and insight we gain from examining this nematode may inform both normal processes such as learning and memory as well as help us understand what goes awry in disease states such as addiction and perhaps attention deficit disorders. Our particular focus is on the olfactory sensory circuit of C. elegans.
1. O'Halloran DM , Hamilton OS , Lee JI , Gallegos M , L'Etoile ND. (2012). Changes in cGMP Levels Affect the Localization of EGL-4 in AWC in Caenorhabditis elegans. PLoS ONE 7(2): e31614.
2. Swarbrick A, Woods S, Shaw A, Balakrishnan A, Phua Y, Chanthery Y, Huskey NE, Lim L, Nguyen A, Ashton L, Sullivan C, Lengyel P, Preiss T, Blelloch R, Weiss W, L'Etoile N, and Goga A. (2010). miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in neuroblastoma. Nature Medicine 16, 1134-1140.
3. Lee, J.I., O'Halloran, D.M., Eastham-Anderson, J., Juang, B.T., Kaye, J.A., Hamilton, O.S., Goga, A., and L'Etoile, N.D. (2010). Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation. Proceedings of the National Academy of Sciences. 107, 6016-6021.
4. O'Halloran, D.M., Altshuler-Keylin, S., Lee, J.I., and L'Etoile, N.D. (2009). Regulators of AWC mediated olfactory plasticity in Caenorhabditis elegans. PLoS Genetics 12:e1000761.
5. Kaye J.A., Rose, N.C., Goldsworthy, B., Goga, A. and L'Etoile, N.D. (2009). A 3'UTR Pumillio- Binding Element Directs Translational Activation in Olfactory Sensory Neurons. Neuron 61, 57-70.
6. Mark Lucanic, Neville Ashcroft, L'Etoile, N.D. and Hwai-Jong Cheng. (2006) The C. elegans p21 activated kinases are differentially required for UNC-6/Netrin commissural motor axon guidance. Development 133, 4549-4559.
7. L'Etoile, N.D., Coburn, C., Eastham, J.R., Kistler, A., Gallegos, G.V., and Bargmann, C.I. (2002). The cyclic GMP-dependent protein kinase EGL-4 regulates olfactory adaptation in C. elegans. Neuron 36, 1079-1089.
8. Dwyer, N.D., Adler, C.E., Crump, J.G., L'Etoile, N.D., Bargmann, C.I. (2001). Polarized dendritic transport and the AP-1 mu1 clathrin adaptor UNC-101 localize odorant receptors to olfactory cilia. Neuron 31, 227-287.
9. L'Etoile, N.D., and Bargmann, C.I. (2000). Olfaction and Odor Discrimination are Mediated by the C elegans Guanylyl Cyclase ODR-1. Neuron 25, 575-586.
10. Komatsu, H., Jin, Y.H., L'Etoile, N.D., Mori, I., Bargmann, C.I., Akaike, N., Ohshima, Y. (1999). Functional reconstitution of a heteromeric cyclic nucleotide-gated channel of Caenorhabditis elegans in cultured cells. Brain Res. 821, 160-168.
11. Martinez, E., Zhou, Q., L'Etoile, N.D., Oelgeschlager, T., Berk, A.J.,and Robert Roeder (1995). Core promoter-specific function of a mutant transcription factor TFIID defective in TATA-box binding. Proceedings of the National Academy of Sciences 92, 11864-8.
12. L'Etoile, N.D., Fahnestock, M.L., Shen, Y., Aebersold, R., and Arnold J. Berk (1994). Human TFIIIC Box B-Binding Subunit. Proceedings of the National Academy of Sciences, 91, 1652-1656.
13. Boulanger, P.A., L'Etoile, N.D., and Arnold J. Berk (1989). A binding domain of human transcription factor IIIC2. Nucleic Acids Research 17, 7761-7770.
14. Yoshinaga, S.K., L'Etoile, N.D., and Arnold J. Berk (1989). Purification and characterization of transcription factor IIIC2. Journal of Biological Chemistry 264, 10726-10731.