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Ralph Marcucio Ph.D.

Development and regeneration of the skeleton

Ralph Marcucio Ph.D.

Dr. Marcucio's research program focuses on two basic science areas. First, using cutting-edge genomic technology, Dr. Marcucio is examining how the entire genome responds to orthopaedic trauma. This genome-mining approach is aimed at determining the global genome response during fracture repair and allows the possibility to generate improved, highly innovative therapies for people undergoing fracture repair. Second, Ralph is examining the role that the brain plays during normal development of the facial skeleton. Many facial birth defects have an underlying brain malformation, and the goal of the research is to generate novel therapeutic approaches that will allow correcting facial malformations prior to birth.

Selected publications:

Hallgrímsson B, Jamniczky HA, Young NM, Rolian C, Schmidt-Ott U, Marcucio RS. The generation of variation and the developmental basis for evolutionary novelty. J Exp Zool B Mol Dev Evol. 2012 Sep; 318(6):501-17.

 Lu C, Xing Z, Wang X, Mao J, Marcucio RS, Miclau T. Anti-inflammatory treatment increases angiogenesis during early fracture healing. Arch Orthop Trauma Surg. 2012 Aug; 132(8):1205-13.

Yu YY, Bahney C, Hu D, Marcucio RS, Miclau Iii T. Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects. J Vis Exp. 2012; (62).

Hu D, Marcucio RS. Neural crest cells pattern the surface cephalic ectoderm during FEZ formation. Dev Dyn. 2012 Apr; 241(4):732-40.

Acaroglu E, Bobe R, Enouf J, Marcucio R, Moldovan F, Moreau A. The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the "metabolic" workgroup of the Fondation Yves Cotrel. Eur Spine J. 2012 Jun; 21(6):1033-42.

Chong HJ, Young NM, Hu D, Jeong J, McMahon AP, Hallgrimsson B, Marcucio RS. Signaling by SHH rescues facial defects following blockade in the brain. Dev Dyn. 2012 Feb; 241(2):247-56.

Dede O, Akel I, Demirkiran G, Yalcin N, Marcucio R, Acaroglu E. Is decreased bone mineral density associated with development of scoliosis? A bipedal osteopenic rat model. Scoliosis. 2011; 6(1):24.

Parsons TE, Schmidt EJ, Boughner JC, Jamniczky HA, Marcucio RS, Hallgrímsson B. Epigenetic integration of the developing brain and face. Dev Dyn. 2011 Oct; 240(10):2233-44.

Lu C, Saless N, Hu D, Wang X, Xing Z, Hou H, Williams B, Swartz HM, Colnot C, Miclau T, Marcucio RS. Mechanical stability affects angiogenesis during early fracture healing. J Orthop Trauma. 2011 Aug; 25(8):494-9.

Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T. Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthritis Cartilage. 2011 Oct; 19(10):1210-8.