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Sunita Ho Ph.D.

Functional Interfaces and Attachment Sites within Vertebrates

Sunita Ho Ph.D.

Mechanical loads manifest into strains within tissues and interfaces of an organ. Strains within tissues are transduced by the cells to produce the needed extracellular matrix proteins to meet functional demands.   This is the general philosophy of research in my laboratory which is within the Division of Biomaterials and Bioengineering.  Our lab has a strong focus on mechanics, materials, and investigating adaptation of tissues/interfaces through spatiotemporal mapping of “mechano-responsiveness”. This is done by correlating mechanical strain induced biochemical signals at soft-hard tissue interfaces using several model systems including the bone-ligament-tooth fibrous joint. Due to the interdisciplinary nature of research, my laboratory is extended to the Molecular Foundry of Lawrence Berkeley National Laboratory, and Stanford Synchrotron Radiation Lightsource (SSRL) at Stanford Linear Accelerator Center (SLAC) with the help of NIH and DOE funded/peer-reviewed proposals.  Mapping of biochemical expressions, physical properties of load bearing tissues, and biomechanics of organs are performed at UCSF, and as a guest scientist at the national laboratories/facilities.

Selected Publications:

S. P. Ho, M. P. Kurylo, T. K. Fong, S. S. Lee, H. D. Wagner, M. I. Ryder, G. W. Marshall, The biomechanical characteristics of the bone-periodontal ligament-cementum complex, Biomaterials, 31(25), 6635-46, 2010 PMID:  20541802; doi:10.1016/j.biomaterials.2010.05.024

J. Hurng, M. P. Kurylo, G. W. Marshall, S. M. Webb, M. I. Ryder, S. P. Ho. Discontinuities in the human bone-PDL-cementum complex. Biomaterials, 32(29), 7106-7117, 2011.  PMID: 21774982; doi: 10.1016/j.biomaterials.2011.06.021

E. Niver, N. Leong, J. Greene, D. Curtis, M. I. Ryder, S. P. Ho. Reduced functional loads alter the physical characteristics of the bone-PDL-cementum complex. Journal of Periodontal Research, 46: 730-741, 2011.

Lin, J.D. and Aloni, S. and Altoe, V. and Webb, S.M. and Ryder, M.I. and Ho, S.P. Elastic discontinuity due to ectopic calcification in a human fibrous joint. Acta Biomaterilia. 2013; 1(9):4787-4795.

Lin, J.D. and Özcoban, H. and Greene, J.P. and Jang, A.T. and Djomehri, S.I. and Fahey, K.P. and Hunter, L.L. and Schneider, G.A. and Ho, S.P. . Biomechanics of a bone-periodontal ligament-tooth fibrous joint. Journal of Biomechanics. 2013; (46):443-449.

Lee JH, Lin JD, Fong JI, Ryder MI, Ho SP. The adaptive nature of the bone-periodontal ligament-cementum complex in a ligature-induced periodontitis rat model. Biomed Res Int. 2013; 2013:876316. PMID: 23936854

Ho SP, Kurylo MP, Grandfield K, Hurng J, Herber RP, Ryder MI, Altoe V, Aloni S, Feng J, Webb S, Marshall GW, Curtis D, Hayter JA, Piennatta P. The Plastic Nature of the Human Bone-Periodontal Ligament-Tooth Fibrous Joint. BONE. 2013 Sep 21. PMID: 24063947

Cover Image, December 2013 issue of BONE.  Ho SP, Kurylo MP, Grandfield K, Hurng J, Herber RP, Ryder MI, Altoe V, Aloni S, Feng J, Webb S, Marshall GW, Curtis D, Hayter JA, Piennatta P. The Plastic Nature of the Human Bone-Periodontal Ligament-Tooth Fibrous Joint. BONE. 2013 Sep 21. PMID: 24063947