University of California San Francisco
Edward Hsiao, MD, PhD
Professor
EDUCATION/CLINICAL TRAINING
MD: MD, PhD, Johns Hopkins Medical School, 2001
Residency: Johns Hopkins Hospital, Baltimore, MD, Internal Medicine, 2001-2004
Fellowship: UCSF, Division of Diabetes, Endocrinology and Metabolism, 2004-2007
Board Certifications: Internal Medicine, 2004; Endocrinology and Metabolism, 2006
ACADEMIC INTERESTS
My research is driven by a desire to understand how major hormonal and regulatory pathways determine the specification, differentiation, and morphogenesis of mesenchymal tissues such as bone, cartilage, muscle, and fat. Mis-regulation of these pathways leads to significant medical diseases, including the inappropriate formation of mineralized tissues in atherosclerosis, heterotopic ossification, and cancer.
My research focuses on understanding how these regulatory signals control normal and pathologic tissue formation as a way to identifying new therapeutic avenues for treating human diseases. Our laboratory takes a comprehensive approach to understanding hormone signaling in human diseases using synthetic biology approaches, mouse models, and human stem cell models.
By combining multiple approaches with state-of-the art methods, our laboratory is working to develop a broader understanding of the biology underlying skeletal development, devise novel therapeutic approaches for treating human skeletal disorders and bone injuries, and examine how hormone signals affect important tissues such as fat, muscle, bone, cartilage, and blood vessels.
CLINICAL INTERESTS:
General Endocrinology with an interest in inherited skeletal diseases, including fibrous dysplasia of the bone (FD), McCune-Albright syndrome (MAS), and fibrodysplasia ossificans progressiva (FOP).
Appointments: 415-353-2350
Availability: General Endocrinology, 3rd Tuesday PM of each month
Laboratory website: https://hsiaolab.ucsf.edu
Education and Training
University of California
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Diversity, Equity, and Inclusion Champion Training
2019
Johns Hopkins University
M.D.
School of Medicine
2001
Associated Programs
Publications
Title
Author (s)
Journal
Date Published
Ther Adv Musculoskelet Dis
2025-12-18
OR23-06 Sensory neuronal ACVR1-mediated neuroimmune contribution to neuropathic pain and heterotopic ossification in fibrodysplasia ossificans progressiva.
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2025-10-22
SAT-781 Exploring the Impact of Osteoporosis Treatments on Posterior Fusion Outcomes in Adult Patients.
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2025-10-22
SUN-725 Sex-Specific Effects of the Gut Microbiome onHeterotopic Ossification inFibrodysplasia Ossificans Progressiva.
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2025-10-22