UCSF Profile
Dr. Le’s research interest is to investigate the structures and functions of enamel extracellular matrix proteins in tooth formation, with particular emphasis on alternatively spliced amelogenins. Mutations in these enamel matrix proteins result in inherited enamel defects, called amelogenesis imperfecta. However, much is still unknown about the roles of these enamel proteins in amelogenesis.
His second clinical research project is to study the pulp revascularization of necrotic immature permanent teeth. The objective of this study is to evaluate a new clinical method for regenerating the functional development of incompletely developed permanent teeth with a diagnosis of pulpal necrosis, and to compare the clinical outcome measures to a current standard method of treatments such as calcium hydroxide or MTA apexification.